Version 5.4
Homo sapiens Protein: PCSK4
Summary
InnateDB Protein IDBP-14646.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCSK4
Protein Name proprotein convertase subtilisin/kexin type 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000300954
InnateDB Gene IDBG-14644 (PCSK4)
Protein Structure
UniProt Annotation
Function Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex. {ECO:0000269PubMed:16040806}.
Subcellular Localization Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Disease Associations
Tissue Specificity Placenta. {ECO:0000269PubMed:16040806}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007339 binding of sperm to zona pellucida
GO:0007340 acrosome reaction
GO:0009566 fertilization
GO:0048240 sperm capacitation
Cellular Component
GO:0002080 acrosomal membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000209 Peptidase S8/S53 domain
IPR002884 Proprotein convertase, P
IPR006212 Furin-like repeat
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR015500 Peptidase S8, subtilisin-related
PFAM PF00082
PF01483
PRINTS PR00723
PIRSF
SMART SM00261
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UW60
PhosphoSite PhosphoSite-Q6UW60
TrEMBL
UniProt Splice Variant
Entrez Gene 54760
UniGene Hs.46884
RefSeq NP_060043
HUGO HGNC:8746
OMIM 600487
CCDS CCDS12069
HPRD
IMGT
EMBL AC027307 AL133566 AY358963 BC036354
GenPept AAH36354 AAQ89322 CAB63719

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca