Version 5.4
Homo sapiens Gene: PCSK4
Summary
InnateDB Gene IDBG-14644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCSK4
Gene Name proprotein convertase subtilisin/kexin type 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115257
Encoded Proteins
IDBP-14646
proprotein convertase subtilisin/kexin type 4
IDBP-762038
IDBP-762243
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in reproduction and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein (proPACAP) and pro-insulin-like growth factor II. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1481428-1490752
Strand Reverse strand
Band p13.3
Transcripts
ENST00000300954 ENSP00000300954
ENST00000441747
ENST00000591303
ENST00000586616
ENST00000586002
ENST00000588671 ENSP00000466742
ENST00000591687
ENST00000590057
ENST00000591201 ENSP00000465102
ENST00000587784
ENST00000588195
ENST00000586074
ENST00000614078
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007339 binding of sperm to zona pellucida
GO:0007340 acrosome reaction
GO:0009566 fertilization
GO:0048240 sperm capacitation
Cellular Component
GO:0002080 acrosomal membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020131
View Gene Order
ENSBTAG00000002305
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.46884
RefSeq NM_017573
HUGO
OMIM
CCDS CCDS12069
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca