InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ephb3

Summary

InnateDB Protein

IDBP-146615.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ephb3

Protein Name

Eph receptor B3

Synonyms

AW456895; Cek10; Etk2; HEK2; MDK5; Sek4; Tyro6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006112

InnateDB Gene

IDBG-146613 (Ephb3)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269PubMed:12408869, ECO:0000269PubMed:14691139, ECO:0000269PubMed:15223334, ECO:0000269PubMed:19598115, ECO:0000269PubMed:8947026, ECO:0000269PubMed:9990854}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14691139}; Single-pass type I membrane protein {ECO:0000269PubMed:14691139}. Cell projection, dendrite {ECO:0000269PubMed:14691139}.

Disease Associations

Tissue Specificity

Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk. Expressed by Paneth and progenitor cells in the crypts of the intestinal epithelium (at protein level). {ECO:0000269PubMed:10704386, ECO:0000269PubMed:12408869}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0001655	urogenital system development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021952	central nervous system projection neuron axonogenesis
GO:0022038	corpus callosum development
GO:0022407	regulation of cell-cell adhesion
GO:0031290	retinal ganglion cell axon guidance
GO:0032314	regulation of Rac GTPase activity
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043088	regulation of Cdc42 GTPase activity
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048538	thymus development
GO:0048546	digestive tract morphogenesis
GO:0050770	regulation of axonogenesis
GO:0051965	positive regulation of synapse assembly
GO:0060021	palate development
GO:0060996	dendritic spine development
GO:0060997	dendritic spine morphogenesis

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

MGI:104770

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
IPR013761 Sterile alpha motif/pointed domain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM