InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ephb3

Summary

InnateDB Gene

IDBG-146613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ephb3

Gene Name

Eph receptor B3

Synonyms

AW456895; Cek10; Etk2; HEK2; MDK5; Sek4; Tyro6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005958

Encoded Proteins

IDBP-146615

Eph receptor B3

IDBP-541587

Eph receptor B3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182580:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:21204755-21223305

Strand

Forward strand

Band

Transcripts

ENSMUST00000006112	ENSMUSP00000006112
ENSMUST00000161063	ENSMUSP00000124375
ENSMUST00000159575
ENSMUST00000160053

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0001655	urogenital system development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021952	central nervous system projection neuron axonogenesis
GO:0022038	corpus callosum development
GO:0022407	regulation of cell-cell adhesion
GO:0031290	retinal ganglion cell axon guidance
GO:0032314	regulation of Rac GTPase activity
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043088	regulation of Cdc42 GTPase activity
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048538	thymus development
GO:0048546	digestive tract morphogenesis
GO:0050770	regulation of axonogenesis
GO:0051965	positive regulation of synapse assembly
GO:0060021	palate development
GO:0060996	dendritic spine development
GO:0060997	dendritic spine morphogenesis