InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mak

Summary

InnateDB Protein

IDBP-146620.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mak

Protein Name

male germ cell-associated kinase

Synonyms

A930010O05Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021792

InnateDB Gene

IDBG-146618 (Mak)

Protein Structure

UniProt Annotation

Function

Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Could have an important function in sensory cells and in spermatogenesis. May participate in signaling pathways used in visual and olfactory sensory transduction. Phosphorylates FZR1 in a cell cycle- dependent manner. Plays a role in the transcriptional coactivation of AR (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Midbody {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269PubMed:21148103}. Photoreceptor inner segment {ECO:0000250}. Note=Localizes in both the connecting cilia and the outer segment axonemes.

Disease Associations

Tissue Specificity

In pre- and postmeiotic male germ cells in testis. In photoreceptor cells of the retina and in the olfactory receptors, and in certain epithelia of the respiratory tract and choroid plexus (brain). {ECO:0000269PubMed:21148103}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0045494	photoreceptor cell maintenance
GO:0046777	protein autophosphorylation

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0030496	midbody
GO:0072686	mitotic spindle

Protein Structure and Domains

PDB ID

MGI:96913

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt