InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lox

Summary

InnateDB Protein

IDBP-146634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lox

Protein Name

lysyl oxidase

Synonyms

AI893619; rrg; TSC-160;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025409

InnateDB Gene

IDBG-146632 (Lox)

Protein Structure

UniProt Annotation

Function

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin.Regulator of Ras expression. May play a role in tumor suppression.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004720	protein-lysine 6-oxidase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process

GO:0001568	blood vessel development
GO:0030199	collagen fibril organization
GO:0030324	lung development
GO:0042060	wound healing
GO:0042493	response to drug
GO:0048251	elastic fiber assembly
GO:0048545	response to steroid hormone
GO:0055114	oxidation-reduction process