InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aplp2

Summary

InnateDB Protein

IDBP-146665.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Aplp2

Protein Name

amyloid beta (A4) precursor-like protein 2

Synonyms

AI790698; APLP-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072428

InnateDB Gene

IDBG-146661 (Aplp2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0042802	identical protein binding
GO:0046914	transition metal ion binding

Biological Process

GO:0001967	suckling behavior
GO:0006878	cellular copper ion homeostasis
GO:0007176	regulation of epidermal growth factor-activated receptor activity
GO:0007617	mating behavior
GO:0007626	locomotory behavior
GO:0008203	cholesterol metabolic process
GO:0010951	negative regulation of endopeptidase activity
GO:0030198	extracellular matrix organization
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0043393	regulation of protein binding
GO:0050885	neuromuscular process controlling balance

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:88047

InterPro

IPR002223 Proteinase inhibitor I2, Kunitz metazoa
IPR008154 Amyloidogenic glycoprotein, extracellular
IPR008155 Amyloidogenic glycoprotein
IPR011178 Amyloidogenic glycoprotein, copper-binding
IPR015849 Amyloidogenic glycoprotein, heparin-binding
IPR019543 Beta-amyloid precursor protein C-terminal
IPR024329 Amyloidogenic glycoprotein, E2 domain

PFAM

PF00014
PF12924
PF02177
PF10515
PF12925

PRINTS

PR00759
PR00203

PIRSF

SMART

SM00131
SM00006

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt