Version 5.4
Mus musculus Gene: Aplp2
Summary
InnateDB Gene IDBG-146661.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aplp2
Gene Name amyloid beta (A4) precursor-like protein 2
Synonyms AI790698; APLP-2
Species Mus musculus
Ensembl Gene ENSMUSG00000031996
Encoded Proteins
IDBP-146665
amyloid beta (A4) precursor-like protein 2
IDBP-146667
amyloid beta (A4) precursor-like protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000084234:
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer\'s disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:31149557-31211815
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000072634 ENSMUSP00000072428
ENSMUST00000079758 ENSMUSP00000078694
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0042802 identical protein binding
GO:0046914 transition metal ion binding
Biological Process
GO:0001967 suckling behavior
GO:0006878 cellular copper ion homeostasis
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007617 mating behavior
GO:0007626 locomotory behavior
GO:0008203 cholesterol metabolic process
GO:0010951 negative regulation of endopeptidase activity
GO:0030198 extracellular matrix organization
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0043393 regulation of protein binding
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000084234
View Gene Order
ENSBTAG00000016168
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q06335
TrEMBL Q3TV12 Q60709 Q61482 Q64348 Q8R0R7
UniProt Splice Variant
Entrez Gene 11804
UniGene Mm.19133 Mm.420165
RefSeq NM_001102455 NM_001102456 NM_009691
OMIM
CCDS CCDS52748 CCDS52749
HPRD
IMGT
MGI ID MGI:88047
MGI Symbol Aplp2
EMBL AC114542 AK160471 BC026491 BC051999 CH466522 CT025678 M97216 U15571 U34291 U37468 U37469 U37470 U37471 U37472 U37473 U37474 U37475 U37476 U37477 U37478 U37479 U37480 U37481 U37482 U37483 U37484 U37485 Z22592 Z27070
GenPept AAA20039 AAA50603 AAB38114 AAB38115 AAC52318 AAH26491 AAH51999 BAE35808 CAA80306 CAA81583 EDL25340
RNA Seq Atlas 11804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca