Mus musculus Protein: Med12l | |||||||||
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Summary | |||||||||
InnateDB Protein | IDBP-146682.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | Med12l | ||||||||
Protein Name | mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)-like | ||||||||
Synonyms | |||||||||
Species | Mus musculus | ||||||||
Ensembl Protein | ENSMUSP00000042269 | ||||||||
InnateDB Gene | IDBG-146676 (Med12l) | ||||||||
Protein Structure | |||||||||
UniProt Annotation | |||||||||
Function | May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}. | ||||||||
Subcellular Localization | Nucleus {ECO:0000305}. | ||||||||
Disease Associations | |||||||||
Tissue Specificity | |||||||||
Comments | |||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||
PDB ID | MGI:2139916 | ||||||||
InterPro |
IPR019035
Mediator complex, subunit Med12 IPR021989 Mediator complex, subunit Med12, catenin-binding IPR021990 Mediator complex, subunit Med12, LCEWAV-domain |
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PFAM |
PF09497
PF12144 PF12145 |
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PRINTS | |||||||||
PIRSF | |||||||||
SMART | |||||||||
TIGRFAMs | |||||||||
Post-translational Modifications | |||||||||
Modification | |||||||||
Cross-References | |||||||||
SwissProt | Q8BQM9 | ||||||||
PhosphoSite | PhosphoSite-Q8BQM9 | ||||||||
TrEMBL | Q6ZPK9 | ||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 329650 | ||||||||
UniGene | Mm.240059 | ||||||||
RefSeq | XP_006501651 | ||||||||
MGI ID | |||||||||
MGI Symbol | Med12l | ||||||||
OMIM | |||||||||
CCDS | |||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | AC115919 AC122038 AK042296 AK047743 AK129412 AK129475 | ||||||||
GenPept | BAC31219 BAC33144 BAC98222 BAC98285 | ||||||||