InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grlf1

Summary

InnateDB Protein

IDBP-146716.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grlf1

Protein Name

glucocorticoid receptor DNA binding factor 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075242

InnateDB Gene

IDBG-146714 (Grlf1)

Protein Structure

UniProt Annotation

Function

Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'- GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005096	GTPase activator activity
GO:0005525	GTP binding

Biological Process

GO:0001843	neural tube closure
GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0030900	forebrain development
GO:0043010	camera-type eye development
GO:0043116	negative regulation of vascular permeability
GO:0043547	positive regulation of GTPase activity
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1929494

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001806 Small GTPase superfamily
IPR002713 FF domain
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00620
PF00071
PF01846

PRINTS

PR00449

PIRSF

SMART

SM00324
SM00441

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt