Mus musculus Gene: Grlf1 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-146714.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Grlf1 | ||||||||||||||||||||||
Gene Name | glucocorticoid receptor DNA binding factor 1 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000058230 | ||||||||||||||||||||||
Encoded Proteins |
glucocorticoid receptor DNA binding factor 1
glucocorticoid receptor DNA binding factor 1
Rho GTPase activating protein 35
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160007:
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 7:16493719-16614993 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A2 | ||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Signaling by Rho GTPases pathway
Axon guidance pathway
Rho GTPase cycle pathway
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
Sema4D mediated inhibition of cell attachment and migration pathway
Signal Transduction pathway
|
||||||||||||||||||||||
KEGG |
Regulation of actin cytoskeleton pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
EGFR1 pathway
TCR pathway
|
||||||||||||||||||||||
REACTOME |
Rho GTPase cycle pathway
Sema4D mediated inhibition of cell attachment and migration pathway
Sema4D in semaphorin signaling pathway
Developmental Biology pathway
Semaphorin interactions pathway
Signaling by Rho GTPases pathway
Axon guidance pathway
Signal Transduction pathway
|
||||||||||||||||||||||
KEGG |
Regulation of actin cytoskeleton pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
Signaling events mediated by focal adhesion kinase
Regulation of RhoA activity
SHP2 signaling
EPHA2 forward signaling
PDGFR-beta signaling pathway
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 232906 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_172739 XM_006539808 XM_006539809 XM_006539810 XM_006539811 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS20851 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1929494 | ||||||||||||||||||||||
MGI Symbol | Arhgap35 | ||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 232906 | ||||||||||||||||||||||