InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Preb

Summary

InnateDB Protein

IDBP-146814.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Preb

Protein Name

prolactin regulatory element binding

Synonyms

C85705;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074387

InnateDB Gene

IDBG-146812 (Preb)

Protein Structure

UniProt Annotation

Function

Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER. {ECO:0000250, ECO:0000269PubMed:11422940}.

Subcellular Localization

Nucleus {ECO:0000250}. Membrane {ECO:0000269PubMed:11422940}; Single-pass membrane protein {ECO:0000269PubMed:11422940}. Endoplasmic reticulum {ECO:0000269PubMed:11422940}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport