InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dact1

Summary

InnateDB Protein

IDBP-146834.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dact1

Protein Name

dapper homolog 1, antagonist of beta-catenin (xenopus)

Synonyms

4921528D17Rik; AI115603; DAPPER; DAPPER1; Frd1; FRODO; Frodo1; MDpr1; MTNG3; THYEX3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058943

InnateDB Gene

IDBG-146832 (Dact1)

Protein Structure

UniProt Annotation

Function

Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome- dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB (By similarity). Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway. The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling (By similarity). May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. {ECO:0000250, ECO:0000269PubMed:17197390, ECO:0000269PubMed:19073771, ECO:0000269PubMed:19701191, ECO:0000269PubMed:20145239, ECO:0000269PubMed:20335472}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell junction, synapse {ECO:0000269PubMed:20335472}. Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in multiple tissues including brain, heart, kidney, liver and testis. {ECO:0000269PubMed:11970895, ECO:0000269PubMed:16881060}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0051018	protein kinase A binding
GO:0070097	delta-catenin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001702	gastrulation with mouth forming second
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0031647	regulation of protein stability
GO:0035412	regulation of catenin import into nucleus
GO:0035413	positive regulation of catenin import into nucleus
GO:0045600	positive regulation of fat cell differentiation
GO:0046329	negative regulation of JNK cascade
GO:0048598	embryonic morphogenesis
GO:0048619	embryonic hindgut morphogenesis
GO:0048813	dendrite morphogenesis
GO:0050808	synapse organization
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle