InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dact1

Summary

InnateDB Gene

IDBG-146832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dact1

Gene Name

dapper homolog 1, antagonist of beta-catenin (xenopus)

Synonyms

4921528D17Rik; AI115603; DAPPER; DAPPER1; Frd1; FRODO; Frodo1; MDpr1; MTNG3; THYEX3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000044548

Encoded Proteins

IDBP-146834

dapper homolog 1, antagonist of beta-catenin (xenopus)

IDBP-535048

dapper homolog 1, antagonist of beta-catenin (xenopus)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165617:
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:71309884-71320107

Strand

Forward strand

Band

Transcripts

ENSMUST00000061273	ENSMUSP00000058943
ENSMUST00000150639	ENSMUSP00000117169

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0051018	protein kinase A binding
GO:0070097	delta-catenin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001702	gastrulation with mouth forming second
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0031647	regulation of protein stability
GO:0035412	regulation of catenin import into nucleus
GO:0035413	positive regulation of catenin import into nucleus
GO:0045600	positive regulation of fat cell differentiation
GO:0045732	positive regulation of protein catabolic process
GO:0046329	negative regulation of JNK cascade
GO:0048598	embryonic morphogenesis
GO:0048619	embryonic hindgut morphogenesis
GO:0048813	dendrite morphogenesis
GO:0050808	synapse organization
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle