Version 5.4
Mus musculus Protein: Nedd9
Summary
InnateDB Protein IDBP-146897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nedd9
Protein Name neural precursor cell expressed, developmentally down-regulated gene 9
Synonyms Cas-L; CasL; HEF1; MEF1; Nedd-9; p105;
Species Mus musculus
Ensembl Protein ENSMUSP00000021794
InnateDB Gene IDBG-146895 (Nedd9)
Protein Structure
UniProt Annotation
Function Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cell cortex {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localizes to both the cell nucleus and the cell periphery. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0007155 cell adhesion
GO:0040008 regulation of growth
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005938 cell cortex
Protein Structure and Domains
PDB ID MGI:97302
InterPro IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR014928 Serine rich protein interaction
IPR021901 CAS family, DUF3513
PFAM PF00018
PF14604
PF07653
PF08824
PF12026
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35177
PhosphoSite PhosphoSite-O35177
TrEMBL
UniProt Splice Variant
Entrez Gene 18003
UniGene Mm.402665
RefSeq NP_001104794
MGI ID
MGI Symbol Nedd9
OMIM
CCDS CCDS49247
HPRD
IMGT
EMBL AF009366 AK030985 AK033729 AK046357 AK054179 AK083374 BC004696 BC053713
GenPept AAB71663 AAH04696 AAH53713 BAC27203 BAC28451 BAC32689 BAC35682 BAC38890

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca