Version 5.4
Homo sapiens Protein: PRM2
Summary
InnateDB Protein IDBP-14704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRM2
Protein Name protamine 2
Synonyms CT94.2;
Species Homo sapiens
Ensembl Protein ENSP00000241808
InnateDB Gene IDBG-14702 (PRM2)
Protein Structure
UniProt Annotation
Function Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity Testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006323 DNA packaging
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0030261 chromosome condensation
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000492 Protamine 2, PRM2
PFAM PF00841
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04554
PhosphoSite PhosphoSite-P04554
TrEMBL Q1LZN1
UniProt Splice Variant
Entrez Gene 5620
UniGene
RefSeq NP_002753
HUGO HGNC:9448
OMIM 182890
CCDS CCDS42118
HPRD 01691
IMGT
EMBL AB281137 AC009121 AF215713 AK131573 AK292447 AK311798 BC005303 BC042671 BC066338 CH471112 M60332 U15422 X07862 Z46940
GenPept AAA63250 AAC50487 AAF34632 AAH05303 AAH42671 AAH66338 BAD18705 BAF36638 BAF85136 BAG34741 CAA30710 CAA87066 EAW85159

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca