InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANXA2

Summary

InnateDB Protein

IDBP-14715.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA2

Protein Name

annexin A2

Synonyms

ANX2; ANX2L4; CAL1H; HEL-S-270; LIP2; LPC2; LPC2D; P36; PAP-IV;

Species

Homo sapiens

Ensembl Protein

ENSP00000346032

InnateDB Gene

IDBG-14711 (ANXA2)

Protein Structure

UniProt Annotation

Function

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	89 [view]
Protein-Protein	89 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008092	cytoskeletal protein binding
GO:0017137	Rab GTPase binding
GO:0019834	phospholipase A2 inhibitor activity
GO:0044548	S100 protein binding
GO:0044822	poly(A) RNA binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001765	membrane raft assembly
GO:0001934	positive regulation of protein phosphorylation
GO:0006900	membrane budding
GO:0007589	body fluid secretion
GO:0030199	collagen fibril organization
GO:0031340	positive regulation of vesicle fusion
GO:0036035	osteoclast development
GO:0042730	fibrinolysis
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0048146	positive regulation of fibroblast proliferation
GO:0051099	positive regulation of binding
GO:0051290	protein heterotetramerization
GO:0071229	cellular response to acid
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0001726	ruffle
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005811	lipid particle
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0009986	cell surface
GO:0016020	membrane
GO:0019897	extrinsic component of plasma membrane
GO:0030496	midbody
GO:0031012	extracellular matrix
GO:0031902	late endosome membrane
GO:0031982	vesicle
GO:0035749	myelin sheath adaxonal region
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043220	Schmidt-Lanterman incisure
GO:0043234	protein complex
GO:0044354	macropinosome
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome