Version 5.4
Homo sapiens Protein: NPR3
Summary
InnateDB Protein IDBP-14723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPR3
Protein Name natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
Synonyms ANP-C; ANPR-C; ANPRC; C5orf23; GUCY2B; NPR-C; NPRC;
Species Homo sapiens
Ensembl Protein ENSP00000265074
InnateDB Gene IDBG-14721 (NPR3)
Protein Structure
UniProt Annotation
Function Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008528 G-protein coupled peptide receptor activity
GO:0016941 natriuretic peptide receptor activity
GO:0017046 peptide hormone binding
GO:0042562 hormone binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001501 skeletal system development
GO:0002158 osteoclast proliferation
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0030157 pancreatic juice secretion
GO:0033688 regulation of osteoblast proliferation
GO:0035810 positive regulation of urine volume
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051000 positive regulation of nitric-oxide synthase activity
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001170 Natriuretic peptide receptor
IPR001828 Extracellular ligand-binding receptor
IPR028082 Periplasmic binding protein-like I
PFAM PF01094
PRINTS PR00255
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P17342
PhosphoSite PhosphoSite-P17342
TrEMBL
UniProt Splice Variant
Entrez Gene 4883
UniGene Hs.619466
RefSeq NP_001191304
HUGO HGNC:7945
OMIM 108962
CCDS CCDS56357
HPRD 00167
IMGT
EMBL AC008766 AC026703 AF025998 AK300094 BC131540 CH471118 M59305 X52282
GenPept AAA51734 AAB88801 AAI31541 BAG61896 CAA36523 EAX10799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca