InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NPR3

Summary

InnateDB Gene

IDBG-14721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPR3

Gene Name

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

Synonyms

ANP-C; ANPR-C; ANPRC; C5orf23; GUCY2B; NPR-C; NPRC

Species

Homo sapiens

Ensembl Gene

ENSG00000113389

Encoded Proteins

IDBP-14723

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

IDBP-363659

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

IDBP-363687

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

IDBP-483987

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

IDBP-481919

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:32689070-32791724

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000265074	ENSP00000265074
ENST00000434067	ENSP00000388408
ENST00000415167	ENSP00000398028
ENST00000509104	ENSP00000425325
ENST00000506712
ENST00000507141	ENSP00000423730

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008528	G-protein coupled peptide receptor activity
GO:0016941	natriuretic peptide receptor activity
GO:0017046	peptide hormone binding
GO:0042562	hormone binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001501	skeletal system development
GO:0002158	osteoclast proliferation
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008217	regulation of blood pressure
GO:0030157	pancreatic juice secretion
GO:0033688	regulation of osteoblast proliferation
GO:0035810	positive regulation of urine volume
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051000	positive regulation of nitric-oxide synthase activity

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022206

View Gene Order

ENSBTAG00000007665

Not yet available

Cross-References

SwissProt

P17342

TrEMBL

C9JK69 D6RDL8 Q60I31

UniProt Splice Variant

Entrez Gene

4883

UniGene

Hs.13528 Hs.619328 Hs.619466

RefSeq

NM_000908 NM_001204375 NM_001204376

HUGO

HGNC:7945

OMIM

108962

CCDS

CCDS47196 CCDS56356 CCDS56357

HPRD

IMGT

EMBL

AB101582 AC008766 AC026703 AF025998 AK300094 BC131540 CH471118 M59305 X52282

GenPept

AAA51734 AAB88801 AAI31541 BAC56126 BAG61896 CAA36523 EAX10798 EAX10799

RNA Seq Atlas

4883