InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Calm3

Summary

InnateDB Protein

IDBP-147272.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Calm3

Protein Name

calmodulin 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019514

InnateDB Gene

IDBG-147270 (Calm3)

Protein Structure

UniProt Annotation

Function

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	70 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0019904	protein domain specific binding
GO:0030234	enzyme regulator activity
GO:0030235	nitric-oxide synthase regulator activity
GO:0031432	titin binding
GO:0031800	type 3 metabotropic glutamate receptor binding
GO:0031996	thioesterase binding
GO:0031997	N-terminal myristoylation domain binding
GO:0043274	phospholipase binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0044325	ion channel binding
GO:0047485	protein N-terminus binding
GO:0048306	calcium-dependent protein binding
GO:0050998	nitric-oxide synthase binding
GO:0072542	protein phosphatase activator activity

Biological Process

GO:0001975	response to amphetamine
GO:0002027	regulation of heart rate
GO:0005513	detection of calcium ion
GO:0007190	activation of adenylate cyclase activity
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019722	calcium-mediated signaling
GO:0021762	substantia nigra development
GO:0030801	positive regulation of cyclic nucleotide metabolic process
GO:0032465	regulation of cytokinesis
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0035307	positive regulation of protein dephosphorylation
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051412	response to corticosterone
GO:0051592	response to calcium ion
GO:0055117	regulation of cardiac muscle contraction
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:1901841	regulation of high voltage-gated calcium channel activity

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0005886	plasma membrane
GO:0030017	sarcomere
GO:0030426	growth cone
GO:0034704	calcium channel complex
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome