Mus musculus Gene: Calm3
Summary
InnateDB Gene IDBG-147270.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Calm3
Gene Name calmodulin 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000019370
Encoded Proteins
calmodulin 3
calmodulin 3
calmodulin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160014:
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16915379-16924114
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000019514 ENSMUSP00000019514
ENSMUST00000172594 ENSMUSP00000133559
ENSMUST00000173139 ENSMUSP00000134395
ENSMUST00000173557
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 70 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008179 adenylate cyclase binding
GO:0019904 protein domain specific binding
GO:0030234 enzyme regulator activity
GO:0030235 nitric-oxide synthase regulator activity
GO:0031432 titin binding
GO:0031800 type 3 metabotropic glutamate receptor binding
GO:0031996 thioesterase binding
GO:0031997 N-terminal myristoylation domain binding
GO:0043274 phospholipase binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044325 ion channel binding
GO:0047485 protein N-terminus binding
GO:0048306 calcium-dependent protein binding
GO:0050998 nitric-oxide synthase binding
GO:0072542 protein phosphatase activator activity
Biological Process
GO:0001975 response to amphetamine
GO:0002027 regulation of heart rate
GO:0005513 detection of calcium ion
GO:0007190 activation of adenylate cyclase activity
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019722 calcium-mediated signaling
GO:0021762 substantia nigra development
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0032465 regulation of cytokinesis
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0035307 positive regulation of protein dephosphorylation
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051412 response to corticosterone
GO:0051592 response to calcium ion
GO:0055117 regulation of cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity
GO:1901841 regulation of high voltage-gated calcium channel activity
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0005886 plasma membrane
GO:0030017 sarcomere
GO:0030426 growth cone
GO:0034704 calcium channel complex
GO:0043005 neuron projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Innate Immune System pathway
Organelle biogenesis and maintenance pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Disease pathway
Hemostasis pathway
Signaling by Wnt pathway
eNOS activation and regulation pathway
Signaling by GPCR pathway
Membrane Trafficking pathway
Ionotropic activity of Kainate Receptors pathway
Activation of Kainate Receptors upon glutamate binding pathway
eNOS activation pathway
Ca-dependent events pathway
Signaling by VEGF pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Signaling by FGFR in disease pathway
DARPP-32 events pathway
beta-catenin independent WNT signaling pathway
Activation of Ca-permeable Kainate Receptor pathway
VEGFR2 mediated cell proliferation pathway
Smooth Muscle Contraction pathway
PLC-gamma1 signalling pathway
Glucose metabolism pathway
Metabolism pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKII pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
EGFR interacts with phospholipase C-gamma pathway
Post NMDA receptor activation events pathway
CaMK IV-mediated phosphorylation of CREB pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CREB phosphorylation through the activation of CaMKK pathway
CaM pathway pathway
Muscle contraction pathway
Signaling by EGFR pathway
Glycogen breakdown (glycogenolysis) pathway
Phospholipase C-mediated cascade pathway
VEGFR2 mediated vascular permeability pathway
VEGFA-VEGFR2 Pathway pathway
Cam-PDE 1 activation pathway
Fc epsilon receptor (FCERI) signaling pathway
Ca2+ pathway pathway
FCERI mediated Ca+2 mobilization pathway
Transcriptional activation of mitochondrial biogenesis pathway
Activation of CaMK IV pathway
Glycogen storage diseases pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
Neuronal System pathway
DAG and IP3 signaling pathway
Metabolism of nitric oxide pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Response to elevated platelet cytosolic Ca2+ pathway
Calmodulin induced events pathway
Signal Transduction pathway
Inositol phosphate metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Mitochondrial biogenesis pathway
Transmission across Chemical Synapses pathway
Signaling by FGFR pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Myoclonic epilepsy of Lafora pathway
Signaling by EGFR in Cancer pathway
Translocation of GLUT4 to the plasma membrane pathway
Metabolism of carbohydrates pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
Olfactory transduction pathway
Insulin signaling pathway pathway
Calcium signaling pathway pathway
Alzheimer's disease pathway
Melanogenesis pathway
Phosphatidylinositol signaling system pathway
GnRH signaling pathway pathway
Long-term potentiation pathway
Glioma pathway
Vascular smooth muscle contraction pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
Phototransduction pathway
Gastric acid secretion pathway
Salivary secretion pathway
INOH
CD4 T cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cam-PDE 1 activation pathway
CaMK IV-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
PLC beta mediated events pathway
DARPP-32 events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Activation of CaMK IV pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Glycogen breakdown (glycogenolysis) pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
eNOS activation pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKK pathway
CREB phosphorylation through the activation of CaMKII pathway
Translocation of GLUT4 to the plasma membrane pathway
Smooth Muscle Contraction pathway
Signaling by FGFR in disease pathway
Organelle biogenesis and maintenance pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
Myoclonic epilepsy of Lafora pathway
beta-catenin independent WNT signaling pathway
eNOS activation and regulation pathway
Signaling by Wnt pathway
Neuronal System pathway
Signaling by VEGF pathway
Mitochondrial biogenesis pathway
Metabolism of carbohydrates pathway
Signaling by GPCR pathway
Innate Immune System pathway
Metabolism of nitric oxide pathway
Ionotropic activity of Kainate Receptors pathway
Platelet activation, signaling and aggregation pathway
VEGFR2 mediated vascular permeability pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Post NMDA receptor activation events pathway
G-protein mediated events pathway
Activation of Kainate Receptors upon glutamate binding pathway
Adaptive Immune System pathway
Diseases associated with visual transduction pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
VEGFA-VEGFR2 Pathway pathway
Transcriptional activation of mitochondrial biogenesis pathway
NGF signalling via TRKA from the plasma membrane pathway
Visual phototransduction pathway
Transmission across Chemical Synapses pathway
Activation of Ca-permeable Kainate Receptor pathway
Muscle contraction pathway
Inositol phosphate metabolism pathway
The phototransduction cascade pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inactivation, recovery and regulation of the phototransduction cascade pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
Ca-dependent events pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Hemostasis pathway
Membrane Trafficking pathway
KEGG
GnRH signaling pathway pathway
Olfactory transduction pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Glioma pathway
Phosphatidylinositol signaling system pathway
Insulin signaling pathway pathway
Calcium signaling pathway pathway
Melanogenesis pathway
Vascular smooth muscle contraction pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Salivary secretion pathway
Phototransduction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.288630 Mm.414403
RefSeq NM_007590
OMIM
CCDS CCDS39789
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas