InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Patl1

Summary

InnateDB Protein

IDBP-147421.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Patl1

Protein Name

protein associated with topoisomerase II homolog 1 (yeast)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060398

InnateDB Gene

IDBG-147419 (Patl1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing specklesLocalization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002151	G-quadruplex RNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008266	poly(U) RNA binding
GO:0030371	translation repressor activity
GO:0034046	poly(G) binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0017148	negative regulation of translation
GO:0033962	cytoplasmic mRNA processing body assembly

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0016605	PML body
GO:0016607	nuclear speck
GO:0030014	CCR4-NOT complex
GO:0043231	intracellular membrane-bounded organelle