InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd40lg

Summary

InnateDB Protein

IDBP-147442.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd40lg

Protein Name

CD40 ligand

Synonyms

CD154; CD40-L; Cd40l; gp39; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; TRAP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033466

InnateDB Gene

IDBG-147440 (Cd40lg)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF5. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein.CD40 ligand, soluble form: Secreted.

Disease Associations

Tissue Specificity

Specifically expressed on activated CD4+ T- lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	0
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005174	CD40 receptor binding
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0030168	platelet activation
GO:0030183	B cell differentiation
GO:0032735	positive regulation of interleukin-12 production
GO:0042100	B cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0045190	isotype switching
GO:0048305	immunoglobulin secretion
GO:0051023	regulation of immunoglobulin secretion
GO:2000353	positive regulation of endothelial cell apoptotic process