InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgef6

Summary

InnateDB Protein

IDBP-147468.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Arhgef6

Protein Name

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Synonyms

1600028C08Rik; 1700038J06Rik; 4930592P22Rik; alpha-PIX;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033468

InnateDB Gene

IDBG-147466 (Arhgef6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0030032	lamellipodium assembly
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

MGI:1920591

InterPro

IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR003096 Smooth muscle protein/calponin
IPR011511 Variant SH3 domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM