Mus musculus Gene: Arhgef6 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-147466.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Arhgef6 | ||||||||||||||||||||||
Gene Name | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | ||||||||||||||||||||||
Synonyms | 1600028C08Rik; 1700038J06Rik; 4930592P22Rik; alpha-PIX | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000031133 | ||||||||||||||||||||||
Encoded Proteins |
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129675:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome X:57231485-57338729 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A6 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
GPCR downstream signaling pathway
Signaling by GPCR pathway
NRAGE signals death through JNK pathway
Signaling by Rho GTPases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Cell-extracellular matrix interactions pathway
Signalling by NGF pathway
Signal Transduction pathway
Cell junction organization pathway
p75 NTR receptor-mediated signalling pathway
Cell-Cell communication pathway
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Pancreatic cancer pathway
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INOH |
Integrin signaling pathway pathway
PDGF signaling pathway pathway
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PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH |
TCR pathway
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REACTOME |
NRAGE signals death through JNK pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway
Cell-extracellular matrix interactions pathway
Signalling by NGF pathway
Cell-Cell communication pathway
Cell junction organization pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Pancreatic cancer pathway
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INOH |
Integrin signaling pathway pathway
PDGF signaling pathway pathway
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PID NCI |
Regulation of RAC1 activity
Integrin-linked kinase signaling
CDC42 signaling events
Regulation of CDC42 activity
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.261443 | ||||||||||||||||||||||
RefSeq | NM_152801 XM_006528313 XM_006528317 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS40984 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||