InnateDB Protein
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IDBP-147523.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Snx10
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Protein Name
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sorting nexin 10
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Synonyms
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2410004M09Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000044165
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InnateDB Gene
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IDBG-147521 (Snx10)
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Protein Structure
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Function |
Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. {ECO:0000269PubMed:22174188}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:22174188}. Endosome membrane {ECO:0000269PubMed:22174188}; Peripheral membrane protein {ECO:0000269PubMed:22174188}; Cytoplasmic side {ECO:0000269PubMed:22174188}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=May also localize to nucleus and endoplasmic reticulum.
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Disease Associations |
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Tissue Specificity |
Expressed in femur, calvariae and teeth. {ECO:0000269PubMed:22174188}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
0
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1919232
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InterPro |
IPR001683
Phox homologous domain
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PFAM |
PF00787
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PRINTS |
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PIRSF |
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SMART |
SM00312
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CWT3
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PhosphoSite |
PhosphoSite-Q9CWT3
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TrEMBL |
Q4FJX6
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UniProt Splice Variant |
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Entrez Gene |
71982
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UniGene |
Mm.489698
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RefSeq |
NP_001120821
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MGI ID |
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MGI Symbol |
Snx10
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OMIM |
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CCDS |
CCDS20136
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HPRD |
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IMGT |
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EMBL |
AC153877
AK010399
AK028163
AK151320
AK151520
AK152004
AK153356
AK166121
AK169110
BC010334
CH466597
CT010276
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GenPept |
AAH10334
BAB26910
BAC25786
BAE30301
BAE30469
BAE30868
BAE31929
BAE38582
BAE40892
CAJ18484
EDK98643
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