InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim54

Summary

InnateDB Protein

IDBP-147660.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim54

Protein Name

tripartite motif-containing 54

Synonyms

4930486E09Rik; 4930566I02Rik; MURF; MURF-3; MuRF3; Rnf30;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013771

InnateDB Gene

IDBG-147658 (Trim54)

Protein Structure

UniProt Annotation

Function

May bind and stabilize microtubules during myotubes formation. {ECO:0000269PubMed:10953002}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:10953002}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269PubMed:10953002}. Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles.

Disease Associations

Tissue Specificity

Selectively expressed in heart and skeletal muscle (at protein level). Also detected in lung and brain at much lower level. {ECO:0000269PubMed:10953002}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0007026	negative regulation of microtubule depolymerization
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0046417	chorismate metabolic process