InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aldh7a1

Summary

InnateDB Protein

IDBP-147697.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh7a1

Protein Name

aldehyde dehydrogenase family 7, member A1

Synonyms

Atq1; D18Wsu181e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065089

InnateDB Gene

IDBG-147695 (Aldh7a1)

Protein Structure

UniProt Annotation

Function

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:20207735}. Nucleus {ECO:0000269PubMed:20207735}. Cytoplasm, cytosol {ECO:0000269PubMed:20207735}.

Disease Associations

Tissue Specificity

Present in liver, kidney, brain and pancreas, and at lower levels in jejunum, duodenum, stomach and testes (at protein level). {ECO:0000269PubMed:20207735}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004043	L-aminoadipate-semialdehyde dehydrogenase activity
GO:0008802	betaine-aldehyde dehydrogenase activity
GO:0016491	oxidoreductase activity