Version 5.4
Mus musculus Protein: Cd83
Summary
InnateDB Protein IDBP-147709.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd83
Protein Name CD83 antigen
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000015540
InnateDB Gene IDBG-147707 (Cd83)
Protein Structure
UniProt Annotation
Function May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Abundantly expressed in spleen and brain, but is also detected in most tissues analyzed. {ECO:0000269PubMed:9799334}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0014070 response to organic cyclic compound
GO:0032713 negative regulation of interleukin-4 production
GO:0032733 positive regulation of interleukin-10 production
GO:0032743 positive regulation of interleukin-2 production
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1328316
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
PFAM PF07679
PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88324
PhosphoSite PhosphoSite-O88324
TrEMBL Q3T9H6
UniProt Splice Variant
Entrez Gene 12522
UniGene Mm.57175
RefSeq NP_033986
MGI ID
MGI Symbol Cd83
OMIM
CCDS CCDS26481
HPRD
IMGT
EMBL AF001036 AF001037 AF001038 AF001039 AF001040 AF001041 AJ245551 AK075888 AK139410 AK154862 AK156386 AK171716 AK172396 AK172449 AK172466 AK172515 BC107344 BC107345 CH466546
GenPept AAC83185 AAC83186 AAI07345 AAI07346 BAC36032 BAE23999 BAE32886 BAE33694 BAE42629 BAE42984 BAE43011 BAE43020 BAE43044 CAB63843 EDL41001

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca