Version 5.4
Mus musculus Protein: Hoxa2
Summary
InnateDB Protein IDBP-147712.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxa2
Protein Name homeobox A2
Synonyms AI324701; Hox-1.11; HOX1.11;
Species Mus musculus
Ensembl Protein ENSMUSP00000014848
InnateDB Gene IDBG-147710 (Hoxa2)
Protein Structure
UniProt Annotation
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001709 cell fate determination
GO:0002076 osteoblast development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007379 segment specification
GO:0007389 pattern specification process
GO:0008045 motor neuron axon guidance
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0021568 rhombomere 2 development
GO:0021569 rhombomere 3 development
GO:0021658 rhombomere 3 morphogenesis
GO:0035284 brain segmentation
GO:0042474 middle ear morphogenesis
GO:0045165 cell fate commitment
GO:0045665 negative regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048703 embryonic viscerocranium morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:96174
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P31245
PhosphoSite PhosphoSite-
TrEMBL Q920U5
UniProt Splice Variant
Entrez Gene 15399
UniGene Mm.131
RefSeq NP_034581
MGI ID
MGI Symbol Hoxa2
OMIM
CCDS CCDS20139
HPRD
IMGT
EMBL AB039184 AB039185 AB039186 AB039187 AB039188 AB039189 AB039190 AB039191 AK134501 BC117105 BC117107 M87801 M93148 M93292 M95599
GenPept AAA37827 AAA37834 AAA37835 AAA37836 AAI17106 AAI17108 BAB68708 BAB68709 BAB68710 BAB68711 BAB68712 BAB68713 BAB68714 BAB68715 BAE22163

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca