InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hoxa2

Summary

InnateDB Gene

IDBG-147710.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxa2

Gene Name

homeobox A2

Synonyms

AI324701; Hox-1.11; HOX1.11

Species

Mus musculus

Ensembl Gene

ENSMUSG00000014704

Encoded Proteins

IDBP-147712

homeobox A2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is expressed in rhombomere 2 and is important for hindbrain formation in the early embryo. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:52162511-52164831

Strand

Reverse strand

Band

Transcripts

ENSMUST00000014848

ENSMUSP00000014848

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001709	cell fate determination
GO:0002076	osteoblast development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007379	segment specification
GO:0007389	pattern specification process
GO:0008045	motor neuron axon guidance
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0021568	rhombomere 2 development
GO:0021569	rhombomere 3 development
GO:0021658	rhombomere 3 morphogenesis
GO:0035284	brain segmentation
GO:0042474	middle ear morphogenesis
GO:0045165	cell fate commitment
GO:0045665	negative regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048703	embryonic viscerocranium morphogenesis
GO:0048704	embryonic skeletal system morphogenesis

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105996

View Gene Order

ENSBTAG00000008138

Not yet available

Cross-References

SwissProt

P31245

TrEMBL

Q3UYP9 Q920T9 Q920U0 Q920U1 Q920U2 Q920U3 Q920U4 Q920U5

UniProt Splice Variant

Entrez Gene

15399

UniGene

Mm.131

RefSeq

NM_010451

OMIM

CCDS

CCDS20139

HPRD

IMGT

MGI ID

MGI:96174

MGI Symbol

Hoxa2

EMBL

AB039184 AB039185 AB039186 AB039187 AB039188 AB039189 AB039190 AB039191 AK134501 BC117105 BC117107 M87801 M93148 M93292 M95599

GenPept

AAA37827 AAA37834 AAA37835 AAA37836 AAI17106 AAI17108 BAB68708 BAB68709 BAB68710 BAB68711 BAB68712 BAB68713 BAB68714 BAB68715 BAE22163

RNA Seq Atlas

15399