InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zic3

Summary

InnateDB Protein

IDBP-147758.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zic3

Protein Name

zinc finger protein of the cerebellum 3

Synonyms

Bn; Ka;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086001

InnateDB Gene

IDBG-147754 (Zic3)

Protein Structure

UniProt Annotation

Function

Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269PubMed:11053430, ECO:0000269PubMed:11959836, ECO:0000269PubMed:15207726}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11238441}. Cytoplasm {ECO:0000269PubMed:11238441}. Note=Translocation to the nucleus requires KPNA1 or KPNA6 (By similarity). Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}.

Disease Associations

Tissue Specificity

CNS. A high level expression is seen in the cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001947	heart looping
GO:0006351	transcription, DNA-templated
GO:0007368	determination of left/right symmetry
GO:0007389	pattern specification process
GO:0009952	anterior/posterior pattern specification
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0035469	determination of pancreatic left/right asymmetry
GO:0035545	determination of left/right asymmetry in nervous system
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071907	determination of digestive tract left/right asymmetry
GO:0071910	determination of liver left/right asymmetry