InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zic3

Summary

InnateDB Gene

IDBG-147754.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zic3

Gene Name

zinc finger protein of the cerebellum 3

Synonyms

Bn; Ka

Species

Mus musculus

Ensembl Gene

ENSMUSG00000067860

Encoded Proteins

IDBP-147756

zinc finger protein of the cerebellum 3

IDBP-147758

zinc finger protein of the cerebellum 3

IDBP-147760

zinc finger protein of the cerebellum 3

IDBP-539268

zinc finger protein of the cerebellum 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156925:
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:58022700-58041736

Strand

Forward strand

Band

Transcripts

ENSMUST00000088631	ENSMUSP00000086003
ENSMUST00000088629	ENSMUSP00000086001
ENSMUST00000088627	ENSMUSP00000085999
ENSMUST00000137687	ENSMUSP00000116383

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001947	heart looping
GO:0006351	transcription, DNA-templated
GO:0007368	determination of left/right symmetry
GO:0007389	pattern specification process
GO:0009952	anterior/posterior pattern specification
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0035469	determination of pancreatic left/right asymmetry
GO:0035545	determination of left/right asymmetry in nervous system
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071907	determination of digestive tract left/right asymmetry
GO:0071910	determination of liver left/right asymmetry

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000156925

View Gene Order

ENSBTAG00000021413

Not yet available

Pathways

NETPATH

REACTOME

REACT_220962

POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway

REACT_216222

Transcriptional regulation of pluripotent stem cells pathway

REACT_188576

Developmental Biology pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_111045

Developmental Biology pathway

REACT_200812

Transcriptional regulation of pluripotent stem cells pathway

REACT_200759

POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q62521

TrEMBL

A2AWK4 A2AWK6

UniProt Splice Variant

Entrez Gene

22773

UniGene

Mm.255890 Mm.418056

RefSeq

NM_009575 XM_006527968 XM_006527970 XM_006527971 XM_006527972 XM_006527973 XM_006527974 XM_006527975 XM_006527969

OMIM

CCDS

CCDS30155

HPRD

IMGT

MGI ID

MGI:106676

MGI Symbol

Zic3

EMBL

AK034780 AK134355 AL671920 AL954389 CH466583 D70849

GenPept

BAA11116 BAC28831 BAE22110 CAM20751 CAM20753 CAM24569 EDL42177 EDL42178

RNA Seq Atlas

22773