InnateDB Protein
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IDBP-147760.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zic3
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Protein Name
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zinc finger protein of the cerebellum 3
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Synonyms
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Bn; Ka;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000085999
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InnateDB Gene
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IDBG-147754 (Zic3)
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Protein Structure
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Function |
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. {ECO:0000269PubMed:11053430, ECO:0000269PubMed:11959836, ECO:0000269PubMed:15207726}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:11238441}. Cytoplasm {ECO:0000269PubMed:11238441}. Note=Translocation to the nucleus requires KPNA1 or KPNA6 (By similarity). Localizes in the cytoplasm in presence of MDFIC overexpression. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
CNS. A high level expression is seen in the cerebellum.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0001947
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heart looping
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GO:0006351
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transcription, DNA-templated
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GO:0007368
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determination of left/right symmetry
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GO:0007389
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pattern specification process
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GO:0009952
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anterior/posterior pattern specification
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GO:0030154
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cell differentiation
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GO:0030324
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lung development
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GO:0035469
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determination of pancreatic left/right asymmetry
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GO:0035545
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determination of left/right asymmetry in nervous system
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0071907
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determination of digestive tract left/right asymmetry
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GO:0071910
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determination of liver left/right asymmetry
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Cellular Component |
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PDB ID |
MGI:106676
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q62521
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PhosphoSite |
PhosphoSite-Q62521
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TrEMBL |
A2AWK6
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UniProt Splice Variant |
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Entrez Gene |
22773
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UniGene |
Mm.418056
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RefSeq |
NP_033601
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MGI ID |
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MGI Symbol |
Zic3
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OMIM |
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CCDS |
CCDS30155
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HPRD |
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IMGT |
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EMBL |
AK034780
AK134355
AL671920
AL954389
CH466583
D70849
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GenPept |
BAA11116
BAC28831
BAE22110
CAM20751
CAM20753
CAM24569
EDL42177
EDL42178
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