InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ercc6

Summary

InnateDB Protein

IDBP-147859.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ercc6

Protein Name

excision repair cross-complementing rodent repair deficiency, complementation group 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066256

InnateDB Gene

IDBG-147857 (Ercc6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008094	DNA-dependent ATPase activity
GO:0032403	protein complex binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000303	response to superoxide
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006284	base-excision repair
GO:0006290	pyrimidine dimer repair
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0007256	activation of JNKK activity
GO:0007257	activation of JUN kinase activity
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411	response to UV
GO:0009636	response to toxic substance
GO:0010165	response to X-ray
GO:0010224	response to UV-B
GO:0010332	response to gamma radiation
GO:0032784	regulation of DNA-templated transcription, elongation
GO:0032786	positive regulation of DNA-templated transcription, elongation
GO:0035264	multicellular organism growth
GO:0045494	photoreceptor cell maintenance

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0008023	transcription elongation factor complex

Protein Structure and Domains

PDB ID

MGI:1100494

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite