InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FLRT2

Summary

InnateDB Protein

IDBP-14786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FLRT2

Protein Name

fibronectin leucine rich transmembrane protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000332879

InnateDB Gene

IDBG-14784 (FLRT2)

Protein Structure

UniProt Annotation

Function

May have a function in cell adhesion and/or receptor signaling.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in pancreas, skeletal muscle, brain, and heart. {ECO:0000269PubMed:10644439}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0045499	chemorepellent activity

Biological Process

GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0008150	biological_process
GO:0035556	intracellular signal transduction
GO:0050919	negative chemotaxis
GO:2001222	regulation of neuron migration

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005887	integral component of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003961 Fibronectin, type III

PFAM