InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgf13

Summary

InnateDB Protein

IDBP-147884.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgf13

Protein Name

fibroblast growth factor 13

Synonyms

Fhf2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033473

InnateDB Gene

IDBG-147880 (Fgf13)

Protein Structure

UniProt Annotation

Function

Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus.Isoform 1 seems not to be involved in neuroblast polarization and migration but regulates axon branching.May regulate voltage-gated sodium channels transport and function.May also play a role in MAPK signaling.

Subcellular Localization

Cell projection, filopodium. Cell projection, growth cone. Cell projection, dendrite. Nucleus. Cytoplasm. Note=Not secreted. Localizes to the lateral membrane and intercalated disks of myocytes.Isoform 1: Nucleus.Isoform 2: Cytoplasm.

Disease Associations

Tissue Specificity

Detected in brain, eye and heart. In brain, the different isoforms display different patterns of expression. Expressed in brain and heart (at protein level). Isoform 3 is highly expressed in cardiac myocytes while isoform 1 is the most abundant in brain. {ECO:0000269PubMed:10644718, ECO:0000269PubMed:21817159, ECO:0000269PubMed:9232594}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008083	growth factor activity
GO:0017080	sodium channel regulator activity
GO:0030295	protein kinase activator activity
GO:0044325	ion channel binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0000165	MAPK cascade
GO:0001764	neuron migration
GO:0007026	negative regulation of microtubule depolymerization
GO:0007612	learning
GO:0007613	memory
GO:0021766	hippocampus development
GO:0021795	cerebral cortex cell migration
GO:0045200	establishment of neuroblast polarity
GO:0045860	positive regulation of protein kinase activity
GO:0046785	microtubule polymerization
GO:0048671	negative regulation of collateral sprouting
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0014704	intercalated disc
GO:0030175	filopodium
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043005	neuron projection