Version 5.4
| Mus musculus Protein: Dtx4 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-147912.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Dtx4 | ||||||||||
| Protein Name | deltex 4 homolog (Drosophila) | ||||||||||
| Synonyms | |||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000040229 | ||||||||||
| InnateDB Gene | IDBG-147910 (Dtx4) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. {ECO:0000250, ECO:0000269PubMed:16923970}. | ||||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | Expressed in brain, testis, embryonic fibroblasts and thymocytes. {ECO:0000269PubMed:15684394, ECO:0000269PubMed:16923970}. | ||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:2672905 | ||||||||||
| InterPro |
IPR001841
Zinc finger, RING-type IPR004170 WWE domain IPR018123 WWE domain, subgroup IPR018957 Zinc finger, C3HC4 RING-type |
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| PFAM |
PF13639
PF14634 PF02825 PF00097 |
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| PRINTS | |||||||||||
| PIRSF | |||||||||||
| SMART |
SM00184
SM00678 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q6PDK8 | ||||||||||
| PhosphoSite | PhosphoSite-Q6PDK8 | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 207521 | ||||||||||
| UniGene | Mm.413196 | ||||||||||
| RefSeq | NP_766030 | ||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Dtx4 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS29631 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AK086624 BC058647 BC069975 | ||||||||||
| GenPept | AAH58647 AAH69975 BAC39704 | ||||||||||