InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppm1a

Summary

InnateDB Protein

IDBP-147923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppm1a

Protein Name

protein phosphatase 1A, magnesium dependent, alpha isoform

Synonyms

2310003C21Rik; 2900017D14Rik; AI427932; AU017636; MMPa-2; MPPa-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021514

InnateDB Gene

IDBG-147921 (Ppm1a)

Protein Structure

UniProt Annotation

Function

Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000250, ECO:0000269PubMed:23088624}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytosol. Membrane. Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0030145	manganese ion binding
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0070412	R-SMAD binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0006499	N-terminal protein myristoylation
GO:0010991	negative regulation of SMAD protein complex assembly
GO:0016055	Wnt signaling pathway
GO:0016311	dephosphorylation
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035970	peptidyl-threonine dephosphorylation
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045893	positive regulation of transcription, DNA-templated