Mus musculus Gene: Ppm1a | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-147921.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Ppm1a | ||||||||||||||||||||||||
Gene Name | protein phosphatase 1A, magnesium dependent, alpha isoform | ||||||||||||||||||||||||
Synonyms | 2310003C21Rik; 2900017D14Rik; AI427932; AU017636; MMPa-2; MPPa-1 | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000021096 | ||||||||||||||||||||||||
Encoded Proteins |
protein phosphatase 1A, magnesium dependent, alpha isoform
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100614:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 12:72761211-72794940 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | C3 | ||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Disease pathway
Regulation of AMPK activity via LKB1 pathway
Signaling by Insulin receptor pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
Loss of Function of TGFBR2 in Cancer pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
PI3K Cascade pathway
Gene Expression pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
IRS-related events pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
IRS-mediated signalling pathway
Generic Transcription Pathway pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
mTOR signalling pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
PKB-mediated events pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
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KEGG |
MAPK signaling pathway pathway
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INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH |
TGF_beta_Receptor pathway
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REACTOME |
Regulation of AMPK activity via LKB1 pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Generic Transcription Pathway pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
PKB-mediated events pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
TGFBR1 KD Mutants in Cancer pathway
IGF1R signaling cascade pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Insulin receptor signalling cascade pathway
Generic Transcription Pathway pathway
PKB-mediated events pathway
IRS-related events triggered by IGF1R pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
mTOR signalling pathway
Loss of Function of TGFBR2 in Cancer pathway
IRS-related events pathway
Gene Expression pathway
IRS-mediated signalling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
IGF1R signaling cascade pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Regulation of AMPK activity via LKB1 pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Loss of Function of SMAD2/3 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Disease pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
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KEGG |
MAPK signaling pathway pathway
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INOH | |||||||||||||||||||||||||
PID NCI |
BMP receptor signaling
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
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Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
UniGene | Mm.313045 Mm.401290 Mm.408115 | ||||||||||||||||||||||||
RefSeq | NM_008910 XM_006515603 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS25970 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||