InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hoxa9

Summary

InnateDB Protein

IDBP-148016.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxa9

Protein Name

homeobox A9

Synonyms

D6a9; Hox-1.7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046939

InnateDB Gene

IDBG-148014 (Hoxa9)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in high level in the embryonic and adult spinal cord with a preference in the posterior region.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	17 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0008584	male gonad development
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0030879	mammary gland development
GO:0035115	embryonic forelimb morphogenesis
GO:0045638	negative regulation of myeloid cell differentiation
GO:0048706	embryonic skeletal system development
GO:0060065	uterus development
GO:0060216	definitive hemopoiesis

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:96180

InterPro

IPR001356 Homeobox domain
IPR006711 Hox9, N-terminal activation domain
IPR009057 Homeodomain-like
IPR017112 Homeobox protein Hox9
IPR020479 Homeodomain, metazoa

PFAM

PF00046
PF04617

PRINTS

PR00024

PIRSF

PIRSF037109

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References