InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hoxa9

Summary

InnateDB Gene

IDBG-148014.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxa9

Gene Name

homeobox A9

Synonyms

D6a9; Hox-1.7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038227

Encoded Proteins

IDBP-148016

homeobox A9

IDBP-251798

homeobox A9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18981407

[Homo sapiens] HOXA9 plays a role in the innate immune response to bacterial infection as a modulator of NF-kappaB-dependent transcription.

Entrez Gene

Summary

This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of similar genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important for hematopoeisis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:52223100-52231089

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048680	ENSMUSP00000046939
ENSMUST00000114425	ENSMUSP00000110068
ENSMUST00000154641
ENSMUST00000156540

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	17 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0008584	male gonad development
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0030879	mammary gland development
GO:0035115	embryonic forelimb morphogenesis
GO:0045638	negative regulation of myeloid cell differentiation
GO:0048706	embryonic skeletal system development
GO:0060065	uterus development
GO:0060216	definitive hemopoiesis

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000078399

View Gene Order

ENSBTAG00000011476

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

P09631

TrEMBL

UniProt Splice Variant

Entrez Gene

15405

UniGene

Mm.4694

RefSeq

NM_010456

OMIM

CCDS

CCDS20146

HPRD

IMGT

MGI ID

MGI:96180

MGI Symbol

Hoxa9

EMBL

AB005457 AB005458 AB008914 BC055059 M28449

GenPept

AAA78790 AAH55059 BAA25800 BAA25801 BAA25802

RNA Seq Atlas

15405