InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hoxa11

Summary

InnateDB Protein

IDBP-148064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hoxa11

Protein Name

homeobox A11

Synonyms

Hox-1.9; Hoxa-11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040920

InnateDB Gene

IDBG-148062 (Hoxa11)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0001656	metanephros development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001759	organ induction
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007338	single fertilization
GO:0007501	mesodermal cell fate specification
GO:0008584	male gonad development
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0010468	regulation of gene expression
GO:0010720	positive regulation of cell development
GO:0030326	embryonic limb morphogenesis
GO:0032330	regulation of chondrocyte differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0035115	embryonic forelimb morphogenesis
GO:0042733	embryonic digit morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048589	developmental growth
GO:0060065	uterus development
GO:0060272	embryonic skeletal joint morphogenesis
GO:0060351	cartilage development involved in endochondral bone morphogenesis

Cellular Component

GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0032993	protein-DNA complex
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:96172

InterPro

IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
IPR021918 Domain of unknown function DUF3528, homeobox protein, eukaryotic

PFAM

PF00046
PF12045

PRINTS

PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt