InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Six6

Summary

InnateDB Protein

IDBP-148130.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Six6

Protein Name

sine oculis-related homeobox 6 homolog (Drosophila)

Synonyms

Optx2; Six9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021519

InnateDB Gene

IDBG-148128 (Six6)

Protein Structure

UniProt Annotation

Function

May be involved in eye development. {ECO:0000303PubMed:10381575, ECO:0000303PubMed:10473118, ECO:0000303PubMed:9724757}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

In the developing embryo, expressed mainly in the ventral optic stalk, optic chiasma, the neural retina and the primordial tissues that give rise to the pituitary/hypothalamus axis. Not expressed in the lens placode. {ECO:0000269PubMed:10381575, ECO:0000269PubMed:10473118}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter