InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mnat1

Summary

InnateDB Protein

IDBP-148232.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mnat1

Protein Name

menage a trois 1

Synonyms

E130115E11Rik; MAT1; P36;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021523

InnateDB Gene

IDBG-148230 (Mnat1)

Protein Structure

UniProt Annotation

Function

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008094	DNA-dependent ATPase activity
GO:0008270	zinc ion binding
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007512	adult heart development
GO:0021591	ventricular system development
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051592	response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005675	holo TFIIH complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:106207

InterPro

IPR001841 Zinc finger, RING-type
IPR003903 Ubiquitin interacting motif
IPR004575 Cdk-activating kinase assembly factor MAT1/Tfb3
IPR015877 Cdk-activating kinase assembly factor MAT1, centre

PFAM

PF13639
PF14634
PF02809
PF06391

PRINTS

PIRSF

PIRSF003338

SMART

SM00184
SM00726

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt