Version 5.4
Mus musculus Protein: Zfp91
Summary
InnateDB Protein IDBP-148292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfp91
Protein Name zinc finger protein 91
Synonyms 9130014I08Rik; A530054C17Rik; AL024263; AW545902; Pzf; Zfp-91;
Species Mus musculus
Ensembl Protein ENSMUSP00000037971
InnateDB Gene IDBG-148288 (Zfp91)
Protein Structure
UniProt Annotation
Function Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Found in all the examined tissues including brain, heart, kidney, lung, liver, spleen, thymus, skeletal muscle, ovary and testis. {ECO:0000269PubMed:7835706}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0070534 protein K63-linked ubiquitination
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:104854
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62511
PhosphoSite PhosphoSite-Q62511
TrEMBL
UniProt Splice Variant
Entrez Gene 109910
UniGene Mm.439025
RefSeq NP_443735
MGI ID
MGI Symbol Zfp91
OMIM
CCDS CCDS37927
HPRD
IMGT
EMBL AK029319 AK051904 AK088933 AK147502 AK147560 AK169477 BC057323 BC064766 BC083000 U05342 U05343
GenPept AAA81911 AAA81913 AAH57323 AAH64766 AAH83000 BAC26394 BAC34808 BAC40660 BAE27956 BAE27996 BAE41195

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca