InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tax1bp1

Summary

InnateDB Protein

IDBP-148307.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tax1bp1

Protein Name

Tax1 (human T-cell leukemia virus type I) binding protein 1

Synonyms

1200003J11Rik; 1700069J21Rik; AA930106; D6Ertd404e; D6Ertd772e; T6bp; TXBP151;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079548

InnateDB Gene

IDBG-148305 (Tax1bp1)

Protein Structure

UniProt Annotation

Function

Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0043130	ubiquitin binding

Biological Process

GO:0006915	apoptotic process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)