InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tax1bp1

Summary

InnateDB Gene

IDBG-148305.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tax1bp1

Gene Name

Tax1 (human T cell leukemia virus type I) binding protein 1

Synonyms

1200003J11Rik; 1700069J21Rik; AA930106; D6Ertd404e; D6Ertd772e; T6bp; TXBP151

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004535

Encoded Proteins

IDBP-148307

Tax1 (human T-cell leukemia virus type I) binding protein 1

IDBP-538349

Tax1 (human T-cell leukemia virus type I) binding protein 1

IDBP-534946

Tax1 (human T-cell leukemia virus type I) binding protein 1

IDBP-533325

Tax1 (human T-cell leukemia virus type I) binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21765415

Tax1bp1 phosphorylation by Chuk is pivotal for the proinflammatory cytokine-dependent assembly of the A20 ubiquitin-editing complex to limit inflammatory gene activation.

InnateDB Annotation from Orthologs

Summary

PMID 17283140

[Homo sapiens] TAX1BP1 is a nuclear receptor co-activator that forms a complex with the glucocorticoid receptor (NR3C1). TAX1BP1 can bind Tax, a human T-cell leukemia virus type 1 oncoprotein, directly and this induces the dissociation of TAX1BP1 from the glucocorticoid receptor-containing protein complex, and represses the co-activator function of TAX1BP1.

PMID 20304918

[Homo sapiens] TAX1BP1 and TNFAIP3 (A20) inhibit antiviral signalling by targeting TBK1/IKKi kinases and disrupting the TRAF3-TBK1-IKKi signalling complex.

PMID 21765415

[Homo sapiens] TAX1BP1 phosphorylation by CHUK is pivotal for the proinflammatory cytokine-dependent assembly of the A20 ubiquitin-editing complex to limit inflammatory gene activation. (Demonstrated in mouse)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106052:
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:52713729-52766780

Strand

Forward strand

Band

Transcripts

ENSMUST00000080723	ENSMUSP00000079548
ENSMUST00000149588	ENSMUSP00000116059
ENSMUST00000128173
ENSMUST00000138040	ENSMUSP00000119522
ENSMUST00000129660	ENSMUSP00000122922
ENSMUST00000147513
ENSMUST00000149586

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0043130	ubiquitin binding

Biological Process

GO:0006915	apoptotic process
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)