InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc9a3r2

Summary

InnateDB Protein

IDBP-148352.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc9a3r2

Protein Name

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

Synonyms

0610011L07Rik; 1200011K07Rik; 2010007A20Rik; E3karp; NHERF-2; Octs2; Sip-1; Sip1; Sryip1; Tka-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002572

InnateDB Gene

IDBG-148350 (Slc9a3r2)

Protein Structure

UniProt Annotation

Function

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus (By similarity). {ECO:0000250}.

Subcellular Localization

Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Apical cell membrane {ECO:0000250}. Note=Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes. Nuclear, in a punctate pattern (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0019902	phosphatase binding

Biological Process

GO:0014067

negative regulation of phosphatidylinositol 3-kinase signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome