InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc9a3r2

Summary

InnateDB Gene

IDBG-148350.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc9a3r2

Gene Name

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

Synonyms

0610011L07Rik; 1200011K07Rik; 2010007A20Rik; E3karp; NHERF-2; Octs2; Sip-1; Sip1; Sryip1; Tka-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002504

Encoded Proteins

IDBP-148352

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

IDBP-148358

solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065054:
This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:24639282-24650305

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000002572	ENSMUSP00000002572
ENSMUST00000019684	ENSMUSP00000019684

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0019902	phosphatase binding

Biological Process

GO:0014067

negative regulation of phosphatidylinositol 3-kinase signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000065054

View Gene Order

ENSBTAG00000013479

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04960

Aldosterone-regulated sodium reabsorption pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04960

Aldosterone-regulated sodium reabsorption pathway

INOH

PID NCI

lysophospholipid_pathway

LPA receptor mediated events

Cross-References

SwissProt

Q9JHL1

TrEMBL

Q6NS54

UniProt Splice Variant

Entrez Gene

65962

UniGene

RefSeq

NM_023055 NM_023449

OMIM

CCDS

CCDS28488 CCDS28489

HPRD

IMGT

MGI ID

MGI:1890662

MGI Symbol

Slc9a3r2

EMBL

AB026489 AB026490 AK002557 AK039491 AK075813 AK084801 AK170057 BC065778 BC070458

GenPept

AAH65778 AAH70458 BAA97568 BAA97569 BAB22185 BAC30366 BAC35980 BAC39282 BAE41537

RNA Seq Atlas

65962